Lady Mary Wortley Montagu (1689-1762) narrates this entry in the Big Ideas That Changed the World series, presenting the story of the development of vaccines.

Lady Mary, an intelligent, lovely White Englishwoman, was infected with smallpox in 1715. The disease left her scarred and possibly contributed to the failure of her marriage, but not before she moved with her husband to the Ottoman Empire and learned there of what came to be called variolation. Inoculating people with an attenuated (hopefully) version of smallpox to cause a mild but immunity-producing spell of the disease was practiced by the Ottomans but remained rare in England until Lady Mary, using her own children, popularized the practice during an epidemic. This graphic novel is illustrated with engaging panels of artwork that broaden its appeal, effectively conveying aspects of the story that extend the enthralling narrative. Taking care to credit innovations in immunology outside of European borders, Brown moves through centuries of thoughtful scientific inquiry and experimentation to thoroughly explain the history of vaccines and their limitless value to the world but also delves into the discouraging story of the anti-vaccination movement. Concluding with information about the Covid-19 pandemic, the narrative easily makes the case that a vaccine for this disease fits quite naturally into eons of scientific progress. Thoroughly researched and fascinating, this effort concludes with outstanding backmatter for a rich, accurate examination of the critical role of vaccines.